Engaging stakeholders effectively is crucial for securing funding and support for R&D in tropical diseases. Establish local partnerships with governmental health agencies and international organizations like the WHO to gain access to resources, knowledge, and networks.

These collaborations could lead to co-funding initiatives, shared research, and expedited regulatory processes. Prioritize building transparent relationships with stakeholders to align objectives and ensure the smooth progression of R&D projects, while also establishing trust within the communities where clinical trials may take place.

Understanding and navigating the regulatory environment is vital for the approval and distribution of new medications. Work closely with local authorities to comply with diverse regulatory requirements across different African regions.

Develop a regulatory strategy that anticipates potential hurdles in the approval process. Consider creating a specialized regulatory affairs team within your department to focus on harmonizing clinical trial protocols with international standards, which can facilitate faster drug approval and distribution.

Explore frameworks for collaboration such as Public-Private Partnerships (PPPs), advance market commitments (AMCs), and Product Development partnerships (PDPs) to further global health initiatives in the region. By leveraging these frameworks, your company can attract investment, share risks, and align incentives with partners.

Additionally, consider participating in disease-specific consortia that bring together multiple stakeholders to focus on R&D for neglected tropical diseases, ensuring that the medications developed are accessible and affordable.

Identify innovative funding mechanisms dedicated to neglected diseases, such as pooled funds, social impact bonds, or venture philanthropy. Present a strong Business Case to global funders, like the Global Fund to Fight AIDS, Tuberculosis and Malaria, emphasizing the potential impact and market for treatments in neglected areas.

Also, explore opportunities for 'blended finance' where public and philanthropic funds de-risk investments to attract private capital.

Establish robust clinical trial protocols by incorporating Best Practices from developed regions, adapted to local conditions. Address infrastructure deficits by partnering with local hospitals and research institutions, and invest in mobile health technologies for better data collection and patient monitoring.

Ensure that trial designs are culturally sensitive and ethical, with the potential to strengthen local Healthcare systems through capacity building and training.

Develop a comprehensive strategic plan that outlines long-term goals for drug development, Manufacturing, and distribution. The plan should include detailed analyses of market needs, potential partnerships, and revenue models.

It should also address how to overcome infrastructure challenges, foster local talent for research and development, and ensure the Sustainability of operations. This plan will serve as a roadmap for the company's efforts to tackle neglected tropical diseases and can be used to communicate the vision to stakeholders for buy-in and support.

Form strategic alliances with universities, NGOs, and biotech firms to accelerate the research and commercialization of new drugs. These partnerships can provide access to novel technologies, specialized expertise, and additional resources.

Develop a partnership framework that allows for shared intellectual property rights and equitable distribution of benefits, ensuring that all parties are incentivized to contribute to the success of the joint initiatives.

Encourage a culture of Innovation within your R&D department to foster the development of new treatments. Utilize Open Innovation platforms to crowdsource ideas and solutions from researchers worldwide.

Implement an internal system for continuous innovation, encouraging your team to propose and experiment with new approaches to drug development. Monitor and implement emerging technologies that can streamline R&D processes, such as Artificial Intelligence for drug discovery.

Build a resilient Supply Chain for the procurement of raw materials and distribution of medications. Diversify suppliers to mitigate risks and ensure the continuous availability of key components for drug Production.

Invest in supply chain technologies for better visibility and control. Consider local production facilities to reduce dependency on imports and enhance the ability to respond quickly to local market demands.

Implement comprehensive Risk Management strategies to anticipate and mitigate risks associated with R&D and operations in Africa. Carry out regular risk assessments to identify potential financial, regulatory, and operational obstacles.

Develop contingency plans for critical risks, such as political instability, currency fluctuations, or supply chain Disruptions. Create a risk-aware culture within the company to ensure that all employees understand their role in managing and reporting risks.